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However, small modifications to both the amino group and the methoxy group at position 5 of the benzothiazole core did not result in any significant increase or decrease in binding activity as measured by the CPMG assay, and no reliable LO-NMR K D data could be obtained for the analogues (Supplementary Table 1)

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Patients receiving B12 for a diagnosed deficiency may begin with more frequent injections before moving to a maintenance schedule